WebSep 18, 2024 · MTX and 10-hydroxyl camptothecin (CPT) were chosen to conjugate through ester linkage. Because of the amphiphilicity and ionicity, MTX-CPT conjugates … WebAug 12, 2024 · Camptothecin (CPT), a potent chemotherapeutic against various cancers, including CRC, has shown the potential to enhance CTL-mediated tumour …
Development of a Prodrug of Camptothecin for Enhanced ... - PubMed
WebNov 28, 2013 · However, administration of a high dose of SN38 or its prodrug CPT-11 is limited by the severe side effects. The most common dose-limiting toxicity (DLT) for CPT-11 or SN38 therapy is delayed diarrhoea and myelosuppression; ~ 35% of the treated patients were reported with Grade 3 or 4 diarrhoea and 14–47 were reported with Grade 3 or 4 … WebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH responsive and targeted drug co-delivery due to the existence of disulfide bond and lactose. 41–44 Then, the CPT-based glyco-nano prodrug system further provides a suitable ... in cite text citation mla
Encapsulation and Controlled Release of a Camptothecin Prodrug …
WebThe clinical efficacy of cytotoxic drugs in the treatment of cancer is often hampered by poor pharmacodynamics and systemic toxicity. Here, we describe the design and synthesis of a new PEG-based system for the delivery of the cytotoxic camptothecin (CPT) into tumor cells that overexpress luteinizing hormone releasing hormone receptor (LHRHR). WebFeb 16, 2024 · The aim of this study was to prepare small-molecule camptothecin (CPT) prodrugs and evaluate their effectiveness in colorectal carcinoma therapy. Prodrug nanoparticles (NPs) were physicochemically characterized and evaluated for their cytotoxicity in human colon cancer (HCT116) cell lines. The antitumor efficacy of the NPs … WebAug 31, 2024 · We report a camptothecin (CPT) prodrug that was well formulated in solution and rapidly transformed into long-circulating nanocomplexes in vivo for … incarnate word qb ward