Chondrocyte affinity peptide

Author: hfqa

August undefined, 2024

WebApr 29, 2024 · Recently, a senolytic peptide, fork head box O transcription factor 4-D-Retro-Inverso (FOXO4-DRI), was reported to selectively kill the senescent fibroblasts. In this study, we hypothesized that FOXO4-DRI treatment could remove the senescent cells in the expanded chondrocytes, thus enhancing their potential in generating high-quality cartilage. WebApr 16, 2015 · A phage display technique was used to identify a chondrocyte-affinity peptide (CAP; DWRVIIPPRPSAC), which is a potential therapeutic agent with better transfection efficiency and …

Cartilage-targeting peptide-modified dual-drug delivery …

WebAug 1, 2024 · Overall, our findings indicated that the as-prepared dual-drug delivery nanoplatform exerted potent anti-inflammation and anti-apoptotic effects, rescued … WebKeywords: extracellular vesicle, exosome, chondrocyte ... Exosome retention in the articular cavity was improved by fusing a chondrocyte-affinity peptide on the exosome surface. The peptide confined the exosomes to the articular cavity and facilitated exosome penetration into the middle zone of the cartilage tissue to achieve targeted ... breville vst041 sandwich toaster

Frontiers The potential therapeutic role of extracellular vesicles in ...

WebOct 1, 2024 · Chondrocyte affinity peptide (CAP) with sequence DWRVIIPPRPSA identified using phage display effectively delivered Hif-2α siRNA to chondrocytes when … WebFeb 15, 2024 · The use of peptides in cartilage tissue engineering, which utilizes a combination of growth factors, cells, and scaffolds. In terms of growth factors, TGF-β … WebMay 1, 2024 · Controlling chondrocyte senescence. New research published in Science Translational Medicine implicates microRNA-204 in the mechanism by which oxidative stress results in altered chondrocyte ... breville vst035 4-slice sandwich toaster

Functional peptides for cartilage repair and regeneration.

Potential of exosomes as cell-free therapy IJN

WebSaid integrin a9β1 ligand has a higher binding affinity with integrin a9β1 than tenascin-C and osteopontin , ... comprising an antibody against osteopontin or fragment peptide portion thereof as an active ingredient. ... promoting chondrocyte differentiation, inhibiting cartilage calcification and inhibiting cartilage degradation, ... WebThe fetal growth plate is primarily composed of three distinct types of chondrocyte types: round, flat, and hypertrophic chondrocytes ( Fig. 1.2 ). The majority of chondrocytes … country initial idWebApr 10, 2024 · Chondrocyte affinity peptide modified exosomes were able to penetrate deep into cartilage [39], [40]. Penetration of cartilage matrix was an indispensable part of our research. Without it, mRNA could hardly reach chondrocyte in vivo. breville vst041 waffle plates

"WebNov 8, 2024 · Pi et al. identified a short CHP sequence with a high binding affinity toward chondrocytes. They introduced a non-viral vector in which fluorescently labeled … " - Chondrocyte affinity peptide

Chondrocyte affinity peptide

Cartilage-targeting mRNA-lipid nanoparticles rescue perifocal …

WebNov 13, 2024 · The affinity of DPI peptides towards BMSCs was analyzed quantitatively by flow cytometry following incubation with FITC-labeled LSP, DPI or RGD. The average … WebBinding assays substantiated that the affinity K d values of four designed cyclic peptides (, , and ) were improved to 23, 67, 42 and 18 μM, respectively, from the 96 μM of linear eILP peptide. Keywords: Chondrocyte senescence; Conformational flexibility; Cyclization; Matrix metallopeptidase 13; Osteoarthritis; Ration peptide design; Self ...

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Webaddition to chondrocyte affinity peptides, MSC affinity peptides can be used to construct cell-free scaffolds used to repair cartilage defects, where they recruit autologous MSCs. Ao et al ... WebJul 1, 2013 · Chondrocyte affinity peptide (CAP) with sequence DWRVIIPPRPSA identified using phage display effectively delivered Hif-2␣ siRNA to chondrocytes when conjugated to PEI [66]. ... Overcoming...

WebIn our study, we identified a chondrocyte-affinity peptide (CAP, DWRVIIPPRPSA) by phage display technology. Subsequent analysis suggests that the peptide can efficiently … WebJul 1, 2013 · Chondrocyte affinity peptide (CAP) with sequence DWRVIIPPRPSA identified using phage display effectively delivered Hif-2␣ siRNA to chondrocytes when …

WebNov 8, 2024 · Pi et al. identified a short CHP sequence with a high binding affinity toward chondrocytes. They introduced a non-viral vector in which fluorescently labeled chondrocyte-affinity peptide (CAP) was covalently bound to polyethyleneimine (PEI) and injected into rabbit knees to target hyaline cartilage. WebAug 27, 2024 · As shown in hematoxylin and eosin (HE) staining (Fig. 3 e), chondrocytes with spindle shape and circular nucleate should be significantly transformed into elongated fibroblast-like cells after treatment of IL-1β for 24 h. MRC-PPL@PSO was able to restore the morphology of most IL-1β pre-treated chondrocytes.

WebMay 28, 2011 · The chondrocyte-affinity peptide (CAP) was identified, and it was suggested that this ligand could specifically bind to chondrocytes [8]. Although its binding receptor has not yet been...

WebBy fusing a chondrocyte-affinity peptide (CAP) with the lysosome-associated membrane glycoprotein 2b protein on the surface of exosomes, we acquire CAP-exosomes that can efficiently encapsulate miR-140, specifically enter, and deliver the cargo into chondrocytes in vitro. CAP-exosomes, in contrast to nontagged exosome vesicles, are retained in ... country in good terms with russiaWebMar 12, 2024 · Materials & methods: Chondrocyte affinity peptide modified PEGylated polyamidoamine conjugates (CAP-PEG-PAMAM) were prepared and rhodamine B … breville vst070 sandwich toasterWebMay 1, 2024 · Controlling chondrocyte senescence. New research published in Science Translational Medicine implicates microRNA-204 in the mechanism by which oxidative stress results in altered chondrocyte ... country in italyWebNov 30, 2024 · Intra-articular injection of an Epas1-targeting siRNA encapsulated in LNPs and the chondrocyte-affinity peptide DWRVIIPPRPSAC alleviated cartilage degeneration and synovial inflammation in a mouse ... country in her heartWebNov 23, 2024 · The chondrocyte-affinity peptide (CAP) was identified, and it was suggested that this ligand could specifically bind to chondrocytes [ 8 ]. Although its binding receptor has not yet been elucidated, the peptide is considered as an excellent candidate for chondrocyte targeting. breville vst072 duraceramic waffle makerWebAlthough still in its infancy, exosome-mediated drug delivery boasts low toxicity, low immunogenicity, and high engineerability, and holds promise for cell-free therapies for a … country initial cnWebFeb 15, 2024 · In addition to chondrocyte affinity peptides, MSC affinity peptides can be used to construct cell-free scaffolds used to repair cartilage defects, where they recruit autologous MSCs. Ao et al. developed several MSC affinity peptides and used them to repair cartilage defects [36-39]. E7 is a peptide screened by phage display with a high … country initials che