Chromomycin-a3

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August undefined, 2024

WebDec 1, 2014 · Chromomycin A3 suppresses cholangiocarcinoma growth by induction of S phase cell cycle arrest and suppression of Sp1-related anti-apoptotic proteins Paksiree Saranaruk, R. Kariya, +7 authors K. Vaeteewoottacharn Biology, Chemistry International journal of molecular medicine 2024 TLDR WebJan 29, 2024 · CMA3 is an anthraquinone glycosidic antibiotic, produced by Streptomyces griseus ( 21 ). The anti-cancer effects of CMA3 have been proposed since the 1960s ( 22, 23 ). Side effects of CMA3 in advanced breast cancers have interrupted that use ( 24) but it is widely used for DNA staining ( 25 ).

Chromomycin A3 - an overview ScienceDirect Topics

WebDec 4, 2014 · Chromomycin A3 / metabolism Chromomycins / pharmacology HCT116 Cells HL-60 Cells Humans Melanoma / drug therapy* Melanoma / metabolism … WebJun 7, 2024 · The Chromomycin A3 (CMA3) and Acridine orange (AO) staining were performed to examine the sperm DNA fragmentation status. CCl4 treatment showed a significant decrease in antioxidant markers and sperm count, viability, normal morphology and motility as well as significantly increased the testicular oxidative stress markers, and … fische online shop aquaristik

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Webchromomycin A3 Acute Tox. 1; H300 <= 100 % For the full text of the H-Statements mentioned in this Section, see Section 16. SECTION 4: First aid measures 4.1 Description of first-aid measures General advice Show this material safety data sheet to the doctor in attendance. If inhaled After inhalation: fresh air. In case of skin contact WebFeb 1, 1974 · Chromomycin A3 shows potent antitumor activity against several experimental tumor systems, including Ehrlich carcinoma, Yoshida sarcoma, sarcoma 180, leukemia SN 36 (Tatsuoka et al., 1958), and lymphoid leukemia L1210 and P388 (National Cancer Institute, 1968). WebApr 27, 2024 · Chromomycin A3 (which is interesting also an antibiotic!), which binds to GC-rich regions of DNA. A Hoechst stain (e.g. 33258 or 33342), that binds to AT-rich regions. Using these DNA stains, we can separate the larger chromosomes from the smaller ones as they will contain more DNA and will thus yield a greater fluorescence signal. campingplatz buntspecht bungalow

Chromomycin A3 ≥95% (HPLC) Sigma-Aldrich

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WebChromomycin A3. 230752-10MG. 80055-168EA 310.68 USD. 80055-168. Chromomycin A3. Chromomycin A3. Antibiotic that inhibits RNA synthesis. Excitation maximum: … WebJan 14, 2024 · Description. Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg2+, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm … fischen tourismusWebChromomycin A3 and mithramycin are antibiotics binding preferentially to the GC-rich regions of DNA. They have excitation maxima at 440 nm and emission maxima at 555 and 575 nm, respectively. Unfortunately the low fluorescence intensity … fische online

"Web#: ALX-380-055 Chromomycin A 3 is a GC-specific DNA ligand which inhibits transcription. It may be used as a fluorescent DNA stain. Antibiotic. Cell permeable fluorescent dye that cann be used with Bisbenzimide H33258 to distinguish chromosomes by their total DNA concentration and their DNA base composition. Does not intercalate. " - Chromomycin-a3

Chromomycin-a3

WebChromomycin A3 Revision Date 20-Feb-2024 www.alfa.com Revision Date 20-Feb-2024 Print Date 20-Feb-2024 Revision Summary SDS authoring systems update, replaces ChemGes SDS No. 7059-24-7. Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the WebChromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of …

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WebDriving Directions to Tulsa, OK including road conditions, live traffic updates, and reviews of local businesses along the way. WebG-C specific intercalating agents [actinomycin D (AMD) and chromomycin A3 at 1 microM] also prevented ER disappearance; ethidium bromide (EB) and quinacrine were ineffective. AMD and CHX operated immediately after their addition to the medium indicating an inhibitory action on the synthesis of an RNA and/or a peptide with high turnover rate ...

WebThe biosynthetic gene cluster of the aureolic acid type antitumor drug chromomycin A3 from S. griseus subsp. griseus has been identified and characterized. It spans 43 kb and … WebChromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. [ 3] It serves as a fluorescent DNA stain. [ 4] It is useful for the detection of protamine deficiency in sperm chromatin.

WebFeb 25, 1997 · The interaction of the two anticancer antibiotics, chromomycin A 3 and mithramycin, with the polynucleotides poly (dG-dC).poly (dC-dG), representative of B-DNA, and poly (dG)·poly (dC), representative of A-DNA, in the presence of Mg 2+ is studied by spectroscopic techniques such as absorbance, fluorescence, and dircular dichroism (CD).

WebChromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. [ 3] It serves as a fluorescent DNA stain. [ 4] It is useful …

WebApplication: Chromomycin A3 is a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye CAS Number: 7059-24-7 Purity: ≥97% Molecular Weight: 1183.25 Molecular Formula: C 57 H 82 … fischen wow classicWebJun 2, 2024 · protamine deficiency by chromomycin A3 (CMA3) staining. In addition, the relationship between the fertilisation rate and sperm ubiquitination was calculated in ICSI candidates. The intensity of ubiquitination showed a significant negative correlation with sperm concentration (r = 0.255, P = 0.032) and a campingplatz butterfly peschiera gardaseeWebChromomycin a3 C57H82O26 CID 656673 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. fischen touristeninformationWebChromomycin A3 (CMA3) Protamination state of the spermatozoa determines its chromatin integrity status. The lesser the protamine content, the poorer the DNA packaging and the higher the sperm DNA damage. CMA3 binds to the sperm DNA deficient of protamine and stains light yellow [74]. The intensity of color is high in sperm with increased prot ... campingplatz camping hain am hainer seeWebDec 4, 2014 · The present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract derived from Streptomyces sp., recovered from Paracuru Beach, located in the northeast region of Brazil. The … fischen thunersee ohne patentWebIn-Person Course Schedule - Industrial Refrigeration …. 1 week ago Web Ends: Apr 21st 2024 5:00PM. Fee: $1,225.00. Register By: Apr 17th 2024 2:17PM. Collapse. This is a … campingplatz buntspecht ferchesarWebDescription. Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced … campingplatz buchholz hamburg