Plants, like many other organisms, have internal clocks that command biological rhythms with a period close to 24 h. These rhythms provide selective advantages because they allow anticipation of the daily changes in environmental conditions (Ouyang et al., 1998; Green et al., 2002). Examples of processes … See more Although it has become clear that posttranscriptional mechanisms contribute significantly to CCG expression, prior to this work, the evidence for regulation at the level of mRNA … See more We would like to thank Lan Xue (Statistical Consulting Service, Department of Statistics, Michigan State University) for help with the statistical analysis of mRNA half-lives. See more WebAmong the latter, differential messenger RNA (mRNA) stability has been hypothesized to control gene expression in response to the clock. However, direct proof that the rate of …
Frontiers Circadian rhythms and post-transcriptional regulation …
WebNov 13, 2024 · Induction of reactive oxygen species both in vitro and in vivo increases PPaRα transcript m 6 A levels, revealing a possible mechanism for circadian disruption on m 6 A mRNA methylation. These data show that m 6 A RNA methylation is important for circadian regulation of downstream genes and lipid metabolism, impacting metabolic … WebPoly (A) tails are 3′ modifications of eukaryotic mRNAs that are important in the control of translation and mRNA stability. We identified hundreds of mouse liver mRNAs that exhibit robust circadian rhythms in the length of their poly (A) tails. Approximately 80% of these are primarily the result of nuclear adenylation coupled with rhythmic ... how to set desktop shortcut
Immune System Killer Cells Controlled by Circadian Rhythms
WebAug 23, 2012 · In mouse liver, the expression of the cold-inducible RNA-binding protein (CIRP) follows a diurnal rhythm that is controlled by systemic cues rather than local oscillators (fig. S1) ().Because a moderate reduction in temperature increases Cirp expression in cultured cells (), we assessed the impact of simulated body temperature … WebFigure 1 The basic circadian clock mechanism in mammals.. Notes: Most cells in the organism have a circadian clock, whose mechanism relies on a set of clock genes. The CLOCK/BMAL1 transcription factor complex positively regulates Per and Cry genes. PER and CRY proteins accumulate and then form complexes, enter the nucleus, and inhibit … WebMay 20, 2011 · AU-rich elements (AREs) are important RNA stability determinants that are present in genes that are involved in host response to microorganisms, ... Circadian control of messenger RNA stability. Association with a sequence-specific messenger RNA decay pathway. Plant Physiol., 138 (2005), pp. 2374-2385. how to set desktop notification for gmail