WebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who are receiving cisplatin ... WebSep 1, 2024 · First, we examined whether cisplatin altered renal iron levels and induced oxidative stress in mice. Cisplatin increased the production of ferrous iron and hydroxyl radical, and they were colocalized in the kidney, suggesting the occurrence of the Fenton reaction (Fig. 1 A–C).Total iron content and TfR and FTH protein expression were …
PSTPIP2 inhibits cisplatin-induced acute kidney injury by …
WebOther pathogenic factors such as FA, oxalate, cisplatin, and gentamicin can also promote the occurrence of Fenton-like chemistry, induce ferroptosis, and lead to AKI. The Fenton-like chemistry can be inhibited by intracellular GPX4, a … WebMay 18, 2024 · The incidence of cisplatin-induced AKI in elderly patients was significantly higher than that of cisplatin-induced renal toxicity partly because three of the included studies defined AKI as a 25% increase in baseline creatinine, one as 20% reduction in Ccr, and two as a 0.3–0.4 mg/dl increase in baseline creatinine, which is more sensitive than … cse citation ucalgary
Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury …
WebDec 21, 2024 · The clinical use of cisplatin has been hampered by its dose-dependent side effects, e.g., nephrotoxicity, and the precise mechanism(s) related to such a cisplatin-induced acute kidney injury (AKI) remain elusive, despite many investigations that were devoted to this subject matter over a period of decades. WebOct 15, 2024 · Cisplatin administration for acute kidney injury (AKI) leads to serious side effects and there is a higher risk of death [2]. In clinical practice, the main causes of AKI are infections, nephrotoxic drugs, diabetes, hypertension, sepsis and cardiovascular disease. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … cse citation free