WebMar 26, 2024 · Collectively, these lines of evidence documented that the three cisplatin-resistant cancer cells showed increased intracellular hypoxia. To unveil the underlying mechanism of the increased intracellular hypoxia, we tested the glucose uptake rate of both BEL7404 and BEL7404DDP cancer cells. WebSep 6, 2012 · Comparing the long-term effects of cisplatin administration at low (20 mg cisplatin/m 2) and high (40 mg/m 2) doses after 4 cycles of daily treatment for 5 days, a small but significant decrease in 51 Cr-EDTA clearance was …
Molecules Free Full-Text The Challenging Treatment of Cisplatin ...
WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … Webglomerular filtration rate, higher serum creatinine, and reduced serum magnesium and potassium levels.4,19,20 On the other hand, the long-term effects of cisplatin on renal ... the cisplatin uptake is due to passive diffusion through the plasma membrane, and the remaining half is mediated by an unknown transporter.22 In 2002, ... foggy rock eatery \u0026 pub blowing rock
Cisplatin uptake and release in pH sensitive zeolitic imidazole …
WebFeb 28, 2024 · Cisplatin is a highly polar species, and its cellular accumulation generally occurs at a slower rate compared with that of other small-molecule anticancer drugs. Apart from passive diffusion, other non-saturable systems, such as fluid-phase endocytosis, may be involved in platinum drug uptake, and evidence for some active or facilitated ... WebTwo major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism … WebFeb 24, 2024 · The 5-year survival rate was 49% for surgery with or without radiation therapy versus 52% (P = .2) for radiation therapy with or without neck dissection. The rate of severe complications was 32% for the surgery group versus 3.8% for the radiation therapy group (P < .001). foggy rock blowing rock menu