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Ctcf is a barrier for 2c-like reprogramming

WebOct 18, 2024 · CTCF controls the metabolic switch occurring at the morula-to-blastocyst transition Summary The eukaryotic genome is organized in 3D at different scales. This structure is driven and maintained by different chromatin states and by architectural factors, such as the zinc finger protein CTCF. WebAug 11, 2024 · Based on the observed CTCF-associated DNA damage in DOX-induced ESC Dux, we speculated that CTCF might represent a barrier for the reprogramming to a 2C-like state. This idea was... We would like to show you a description here but the site won’t allow us.

Reprogramming of fibroblast cells to totipotent state by DNA ...

WebOct 15, 2024 · One of the earliest identified roadblocks to 2C-like reprogramming is the histone H3K4/K9 demethylase, KDM1A/LSD1. KDM1A/LSD1 mutant mESCs harbor significantly higher MuERVL transcript levels [ 47 ], indicating that repressive heterochromatin restrains MuERVL transcription [ 54, 117 ]. Web(2024) Olbrich et al. Nature Communications. Totipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with … datapoint audiology clinic https://iaclean.com

CTCF is a barrier for 2C-like reprogramming - mendeley.com

WebDec 22, 2024 · 1 1 CTCF is a Barrier for Totipotent-like Reprogramming 2 Teresa Olbrich1, Maria Vega-Sendino1, Desiree Tillo2, Wei Wu1, Nicholas Zolnerowich1, Andy D. 3 Tran3, Catherine N. Domingo1, Mariajose Franco1, Marta Markiewicz-Potoczny1, Gianluca 4 Pegoraro4, Peter C. FitzGerald5, Michael J. Kruhlak3, Eros Lazzerini-Denchi1, … WebHere, we show that the CCCTC-binding factor (CTCF) is a barrier for 2C-like reprogramming. Indeed, forced conversion to a 2C-like state by the transcription factor DUX is associated with DNA damage at a subset of CTCF binding sites. Depletion of CTCF in ESC efficiently promotes spontaneous and asynchronous conversion to a 2C-like … WebAug 11, 2024 · CTCF is a barrier for 2C-like reprogramming DOI: 10.1038/s41467-021-25072-x License Authors: Teresa Olbrich Maria Vega-Sendino Desiree Tillo Wei Wu … datapoint fisgov account logon

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Category:DNA replication fork speed underlies cell fate changes …

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Ctcf is a barrier for 2c-like reprogramming

DNA replication fork speed underlies cell fate changes and

WebAug 3, 2015 · In the comparison of p60KD-induced 2C–like cells: with zygote p=1; with 2-cell p=2.092e-13; with 4-cell p=0.051; with 8-cell p=1; with 16-cell p=1; with early blastocyst p=1. In the comparison of... WebNov 15, 2024 · In line with CTCF acting as a barrier to conversion, the lost expression of this critical chromatin regulator in ESCs eased their spontaneous and asynchronous …

Ctcf is a barrier for 2c-like reprogramming

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WebMay 20, 2024 · A novel model to study the transition has been recently established, named the 2-cell-like (2C-like) model. The 2C-like cells are rare totipotent-like cells in the mouse embryonic stem cell (mESC) culture. Pluripotent mESCs can spontaneously transit into and out of the 2C-like state. WebCTCF is a barrier for 2C-like reprogramming Nature Communications August 11, 2024 See publication Following Trypanosoma cruzi RPA …

WebMay 27, 2024 · Although not strictly totipotent, 2CLCs are considered totipotent-like cells and are therefore a powerful cellular model to study molecular features related to totipotency. 2CLCs emerge most... WebAug 11, 2024 · However, the molecular determinants of 2C-like conversion have not been completely elucidated. Here, we show that the CCCTC-binding factor (CTCF) is a …

WebAug 11, 2024 · Europe PMC is an archive of life sciences journal literature.

WebMar 7, 2024 · Perturbations that slow replication fork speed promote 2-cell-like cell emergence and improve somatic cell nuclear transfer reprogramming and formation of …

WebCTCF is a Barrier for Totipotent-like Reprogramming Relations BioProject PRJNA693454 SRA SRP302520 Supplementary file Size Download File type/resource … marti pellow todayWebAug 22, 2024 · Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M et al (2024) CTCF is a barrier for 2C-like reprogramming. Nature Communications 12: 4856 Crossref CAS PubMed Web of Science® Google Scholar data point eye clinicWebCTCF is a barrier for 2C-like reprogramming. T Olbrich, M Vega-Sendino, D Tillo, W Wu, N Zolnerowich, R Pavani, ... Nature Communications 12 (1), 4856, 2024. 28: 2024: Methylated cytosines mutate to transcription factor … marti pinterest