WebJul 6, 2024 · Cytoplasmic DNA sensing pathways. Cytoplasmic DNA is a danger-associated molecular pattern when it translocates into the cytoplasm from the nucleus (e.g. through genomic instability that facilitates the inclusion of damaged DNA in micronuclei prone to lose their membrane), by an accumulation of mitochondrial DNA following … WebMar 26, 2009 · Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (also known as cryopyrin and NLRP3)-independent inflammasome, which activates caspase-1 leading to maturation of pro-interleukin-1beta and inflammation. The nature of the cytoplasmic-DNA-sensing inflamma …
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
WebOct 19, 2010 · Innate immune responses to pathogens are often triggered by nucleic acids, including DNA delivered to the cytoplasm of cells. IFI16 is a newly identified cytoplasmic DNA sensor that induces the ... WebThe cGAS/STING pathway is a cytoplasmic DNA sensor, and activation of the cGAS/STING pathway leads to two independent downstream pathways: type I IFNs through IRF3 and proinflammatory responses through NFκB16. Both the IRF3- and NF-κB-dependent pathways lead to the production of inflammatory growth factors and … immoweb colocation
KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY - MSigDB
WebDive into the research topics of 'Cytoplasmic DNA: sources, sensing, and role in aging and disease'. Together they form a unique fingerprint. DNA Medicine & Life Sciences 100%. Inflammation Mediators Medicine & Life Sciences 57%. Therapeutics Medicine & Life Sciences 14%. View full fingerprint ... WebFeb 6, 2024 · Toll-like receptor 9 (TLR9), the founding member of the innate immune sensors for DNA, is composed of a leucine-rich repeat (LRR) domain and a Toll/IL-1 receptor (TIR) domain. TLR9 was discovered first in mouse macrophages and later in human cells ( FIGURE 1) ( 10, 41 ). As is the case for most other TLR family members, … WebFeb 6, 2024 · This DNA is sensed by certain receptors that mediate cytokine production and, in some cases, initiate an inflammatory and lytic form of cell death called pyroptosis. Dysregulation of these DNA-sensing pathways is thought to contribute to autoimmune diseases and the development of cancer. immoweb connexion