WebJan 31, 2024 · Noteworthy, we demonstrated that the saturation of fatty acids exerted great influence on colloidal stability of prodrug NPs, thus affecting their in vivo … WebAug 4, 2016 · This novel prodrug-nanosystem addresses concerns related to the low drug loading and inefficient drug release from hydrophobic prodrugs of PTX, and provides possibilities for the development of redox dual-sensitive conjugates or polymers for efficient anticancer drug delivery. KEYWORDS: Paclitaxel small-molecule prodrug single thioether
Structure-Activity Relationship of pH-Sensitive Doxorubicin-Fatty …
WebMay 30, 2024 · Its substrates include MAGs of different fatty acid chain lengths and degrees of saturation (e.g., 2-arachidonoyl glycerol, 2-oleylglycerol, 2 ... which may serve as a CNS-penetrating prodrug, also showed an MAGL-inhibitory activity in the low micromolar range. Furthermore, replacing two of the four ethyl groups in disulfiram ... WebNov 26, 2024 · Here, three paclitaxel prodrugs were synthesized by conjugating paclitaxel with octanol (C 8 ), decanol (C 10) or dodecanol (C 12) through disulfide bond. The three prodrugs could form homogeneous nanoparticles, with over 50% drug loading and redox dual-responsivity. pally epic 1.5
Rational design of a new cytarabine-based prodrug …
WebJan 22, 2024 · Inspired by the above findings, mixed polyunsaturated fatty acids (MPUFAs), mainly composed of omega-3 PUFAs such as DHA and eicosapentaenoic acid (EPA), were extracted and purified by simple hydrolysis of fish oil and used to prepare an ion-pairing prodrug conjugated with the potent antitumor drug doxorubicin (DOX), as shown in … WebThe different lipid-drug conjugates (triglyceride-, fatty acids, phospholipid-, and steroid-based prodrugs), the physiological barriers that challenge the absorption of these … WebThe designed SCFA prodrugs consist of enzyme-metabolizable amphiphilic block copolymers, [poly(ethylene glycol)-b-poly(vinyl ester)s] conjugated to propionic acid (PA) … sunbed tanning shops near me