WebMay 13, 2024 · Figure 1. Lipid-binding abilities of some SH2 domains may contribute to spatio-temporal coordination of tyrosine kinase signaling hub dynamics. Alternative … WebOct 1, 1999 · Phosphotyrosine binding (PTB) domains have been identified in a large number of proteins. In proteins like Shc and IRS-1, the PTB domain binds in a phosphotyrosine …
Evaluation of the Interaction between ... - Wiley Online Library
WebAll three SHC1 proteins share the same domain arrangement consisting of an N-terminal phosphotyrosine-binding(PTB) domain and a C-terminal Src-homology2(SH2) domain. Both of the domains for the three proteins can bind to tyrosine-phosphorylated proteins but they are different in their phosphopeptide-binding specificities. WebDec 19, 2014 · SH2D5 is a mammalian-specific, uncharacterized adaptor-like protein that contains an N-terminal phosphotyrosine-binding domain and a C-terminal Src homology 2 (SH2) domain. We show that SH2D5 is highly enriched in adult mouse brain, particularly in Purkinjie cells in the cerebellum and the cornu amm … hozier at red rocks
SHC1 - Wikipedia
WebMar 1, 2002 · Phosphotyrosine-binding (PTB) domains — also called phosphotyrosine-interacting domains ( PIDs) — were first identified in the SH2-domain-containing adaptor … WebPhosphorylation may be viewed as a device to control the assembly of protein complexes, and thereby to regulate the dynamic behavior of the cell. Phospho-dependent interaction … WebPhosphotyrosine-Binding Domain. The case for PTB domain adaptors regulating LDL receptor internalization was closed with the identification of the gene responsible for … hozier at the greek theatre